BioinvestGPT

BioinvestGPT ApS · Research use only

NCT04158336 (ZN-c3 in Solid Tumors): BVCT ex-ante prediction vs. reported outcome

On 25 May 2023, BioinvestGPT's BVCT predicted technical failure and commercial failure for this trial. The 18 Jun 2024 readout is classified on the dashboard as True Negative (TN), a correct prediction. Recorded clinical-benefit conclusion: statistically insignificant and commercially insufficient.

Clinical Trial

NCTID
NCT04158336
Drug Name
ZN-c3
Drug MoA
Wee1 inhibitor
Drug Modality
small molecule
Drug Class
First-In-Class
Therapeutic Area
Neoplasms
Indication
Solid Tumors
Human Patients
146
Sponsor
Zentalis Pharmaceuticals
Phase
Phase 1

Prediction of , index 1077

Prospective Prediction
Prediction Index
1077
Prediction Date
Commercial Prediction
FAILURE (commercially insufficient clinical benefit regardless of CCNE1 expression)
Technical Prediction
FAILURE (statistically insignificant clinical efficacy and high clinical toxicity)

Readout of

Prediction Validation
Readout Date
Prediction To Readout
390 days in advance
Readout Data Interpretation
high toxicity resulting in clinical hold.
Press Release
Prediction Result
Prediction Accuracy
Correct Prediction
Clinical Benefit Conclusion
statistically insignificant and commercially insufficient
Prediction Classification
True Negative (TN)

ClinicalTrials.gov record

ClinicalTrials.gov record, retrieved 2026-09-24. Third-party data.

Official title
A Phase 1 Study of ZN-c3 as a Single Agent in Subjects With Solid Tumors
Phase
Phase 1
Status
Completed
Enrollment
274
Lead sponsor
K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
Conditions
Solid Tumor
Interventions
DRUG: Azenosertib
Design
Randomized · Parallel · None
Primary purpose
Treatment
Start
2019-11-01
Primary completion
2025-05-06
Completion
2025-05-06
Primary outcomes
  • Dose Escalation (Through completion, average of 1 year)
  • Food Effect Cohort (Through completion, approx 6 months)
  • Food Effect Cohort (Through completion, approximately 6 months)
  • Food Effect Cohort (Through completion approximately 6 month)
  • Food Effect Cohort (Through completion, approximately 6 mth)

NCT04158336 on ClinicalTrials.gov

Return to the dashboardClinicalTrials.gov

How to read these records: evidence · methodology · all trials